Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway

Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT), which is a cellular de-differentiation program that promotes invasion and metastasis, confers tumor cells with cancer stem cell (CSC)-like characteristics, and increases therapeutic resistance. However, the mechanisms t...

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Detalles Bibliográficos
Autores principales: Wang, Yifan, Liu, Jingyi, Ying, Xuhua, Lin, Pengnian Charles, Zhou, Binhua P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837350/
https://www.ncbi.nlm.nih.gov/pubmed/27094683
http://dx.doi.org/10.1038/srep24606
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author Wang, Yifan
Liu, Jingyi
Ying, Xuhua
Lin, Pengnian Charles
Zhou, Binhua P.
author_facet Wang, Yifan
Liu, Jingyi
Ying, Xuhua
Lin, Pengnian Charles
Zhou, Binhua P.
author_sort Wang, Yifan
collection PubMed
description Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT), which is a cellular de-differentiation program that promotes invasion and metastasis, confers tumor cells with cancer stem cell (CSC)-like characteristics, and increases therapeutic resistance. However, the mechanisms that facilitate the functions of Twist remain unclear. Here we report that Twist overexpression increased expression of PAR1, an upstream regulator of the Hippo pathway; PAR1 promotes invasion, migration, and CSC-like properties in breast cancer by activating the transcriptional co-activator TAZ. Our study indicates that Hippo pathway inhibition is required for the increased migratory and invasiveness ability of breast cancer cells in Twist-mediated EMT.
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spelling pubmed-48373502016-04-27 Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway Wang, Yifan Liu, Jingyi Ying, Xuhua Lin, Pengnian Charles Zhou, Binhua P. Sci Rep Article Twist is a key transcription factor for Epithelial-mesenchymal transition (EMT), which is a cellular de-differentiation program that promotes invasion and metastasis, confers tumor cells with cancer stem cell (CSC)-like characteristics, and increases therapeutic resistance. However, the mechanisms that facilitate the functions of Twist remain unclear. Here we report that Twist overexpression increased expression of PAR1, an upstream regulator of the Hippo pathway; PAR1 promotes invasion, migration, and CSC-like properties in breast cancer by activating the transcriptional co-activator TAZ. Our study indicates that Hippo pathway inhibition is required for the increased migratory and invasiveness ability of breast cancer cells in Twist-mediated EMT. Nature Publishing Group 2016-04-20 /pmc/articles/PMC4837350/ /pubmed/27094683 http://dx.doi.org/10.1038/srep24606 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Yifan
Liu, Jingyi
Ying, Xuhua
Lin, Pengnian Charles
Zhou, Binhua P.
Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
title Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
title_full Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
title_fullStr Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
title_full_unstemmed Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
title_short Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway
title_sort twist-mediated epithelial-mesenchymal transition promotes breast tumor cell invasion via inhibition of hippo pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837350/
https://www.ncbi.nlm.nih.gov/pubmed/27094683
http://dx.doi.org/10.1038/srep24606
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