Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice

Obesity is associated with local tissue hypoxia and elevated hypoxia-inducible factor 1 alpha (HIF-1α) in metabolic tissues. Prolyl hydroxylases (PHDs) play an important role in regulating HIF-α isoform stability. In the present study, we investigated the consequence of whole-body PHD1 gene (Egln2)...

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Detalles Bibliográficos
Autores principales: Thomas, Amandine, Belaidi, Elise, Aron-Wisnewsky, Judith, van der Zon, Gerard C., Levy, Patrick, Clement, Karine, Pepin, Jean-Louis, Godin-Ribuot, Diane, Guigas, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837354/
https://www.ncbi.nlm.nih.gov/pubmed/27094951
http://dx.doi.org/10.1038/srep24618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837354/
https://www.ncbi.nlm.nih.gov/pubmed/27094951
http://dx.doi.org/10.1038/srep24618

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