Dimerization of human uridine diphosphate glucuronosyltransferase allozymes 1A1 and 1A9 alters their quercetin glucuronidation activities

Uridine diphosphate glucuronosyltransferase 1A (UGT1A) is a major phase II drug-metabolism enzyme superfamily involved in the glucuronidation of endobiotics and xenobiotics in humans. Many polymorphisms in UGT1A genes are reported to inhibit or decrease UGT1A activity. In this study, two UGT1A1 allo...

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Detalles Bibliográficos
Autores principales: Liu, Yan-Qing, Yuan, Ling-Min, Gao, Zhang-Zhao, Xiao, Yong-Sheng, Sun, Hong-Ying, Yu, Lu-Shan, Zeng, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837415/
https://www.ncbi.nlm.nih.gov/pubmed/27025983
http://dx.doi.org/10.1038/srep23763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837415/
https://www.ncbi.nlm.nih.gov/pubmed/27025983
http://dx.doi.org/10.1038/srep23763

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