The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Many transformed cells exhibit altered glucose metabolism and increased utilization of glutamine for anabolic and bioenergetic processes. These metabolic adaptations, which accompany tumorigenesis, are driven by oncogenic signals. Here we report that the transcription factor c-Jun, product of the pr...

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Detalles Bibliográficos
Autores principales: Lukey, Michael J., Greene, Kai Su, Erickson, Jon W., Wilson, Kristin F., Cerione, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837472/
https://www.ncbi.nlm.nih.gov/pubmed/27089238
http://dx.doi.org/10.1038/ncomms11321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837472/
https://www.ncbi.nlm.nih.gov/pubmed/27089238
http://dx.doi.org/10.1038/ncomms11321

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