Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations

Glycogen is a branched glucose polymer and serves as an important energy store. Its debranching is a critical step in its mobilization. In animals and fungi, the 170 kDa glycogen debranching enzyme (GDE) catalyses this reaction. GDE deficiencies in humans are associated with severe diseases collecti...

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Detalles Bibliográficos
Autores principales: Zhai, Liting, Feng, Lingling, Xia, Lin, Yin, Huiyong, Xiang, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837477/
https://www.ncbi.nlm.nih.gov/pubmed/27088557
http://dx.doi.org/10.1038/ncomms11229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837477/
https://www.ncbi.nlm.nih.gov/pubmed/27088557
http://dx.doi.org/10.1038/ncomms11229

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