Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301

Mitotic inhibitors are widely utilized chemotherapeutic agents that take advantage of mitotic defects in cancer cells. We have identified a novel class of piperazine-based mitotic inhibitors, of which AK301 is the most potent derivative identified to date (EC(50) < 200 nM). Colon cancer cells arr...

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Detalles Bibliográficos
Autores principales: Chopra, Avijeet, Bond, Michael J., Bleiler, Marina, Yeagley, Michelle, Wright, Dennis, Giardina, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838221/
https://www.ncbi.nlm.nih.gov/pubmed/27097159
http://dx.doi.org/10.1371/journal.pone.0153818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838221/
https://www.ncbi.nlm.nih.gov/pubmed/27097159
http://dx.doi.org/10.1371/journal.pone.0153818

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