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Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301
Mitotic inhibitors are widely utilized chemotherapeutic agents that take advantage of mitotic defects in cancer cells. We have identified a novel class of piperazine-based mitotic inhibitors, of which AK301 is the most potent derivative identified to date (EC(50) < 200 nM). Colon cancer cells arr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838221/ https://www.ncbi.nlm.nih.gov/pubmed/27097159 http://dx.doi.org/10.1371/journal.pone.0153818 |