Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway

Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential molecular therapeutic target in treatment of various cancers. Herein, we report the synthesis of trisubstituted-imidazoles and identified 2-chloro-3-(4, 5-diphenyl-1H-imidazol-2-yl) pyridine (CIP) as lead cytotoxic...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohan, Chakrabhavi Dhananjaya, Srinivasa, V., Rangappa, Shobith, Mervin, Lewis, Mohan, Surender, Paricharak, Shardul, Baday, Sefer, Li, Feng, Shanmugam, Muthu K., Chinnathambi, Arunachalam, Zayed, M. E., Alharbi, Sulaiman Ali, Bender, Andreas, Sethi, Gautam, Basappa, Rangappa, Kanchugarakoppal S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838272/
https://www.ncbi.nlm.nih.gov/pubmed/27097161
http://dx.doi.org/10.1371/journal.pone.0153155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838272/
https://www.ncbi.nlm.nih.gov/pubmed/27097161
http://dx.doi.org/10.1371/journal.pone.0153155

Ejemplares similares