Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies

Cerebral Cavernous Malformation (CCM) is a major cerebrovascular disease of proven genetic origin affecting 0.3–0.5% of the general population. It is characterized by abnormally enlarged and leaky capillaries, which predispose to seizures, focal neurological deficits and intracerebral hemorrhage. Ca...

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Detalles Bibliográficos
Autores principales: Marchi, Saverio, Trapani, Eliana, Corricelli, Mariangela, Goitre, Luca, Pinton, Paolo, Retta, Saverio Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838318/
https://www.ncbi.nlm.nih.gov/pubmed/27141412
http://dx.doi.org/10.1080/21675511.2016.1142640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838318/
https://www.ncbi.nlm.nih.gov/pubmed/27141412
http://dx.doi.org/10.1080/21675511.2016.1142640

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