ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma

TP63, a member of the p53 gene family gene, encodes the ΔNp63 protein and is one of the most frequently amplified genes in squamous cell carcinomas (SCC) of the head and neck (HNSCC) and lungs (LUSC). Using an epiallelic series of siRNAs with intrinsically different knockdown abilities, we show that...

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Detalles Bibliográficos
Autores principales: Bretz, Anne Catherine, Gittler, Miriam P., Charles, Joël P., Gremke, Niklas, Eckhardt, Ines, Mernberger, Marco, Mandic, Robert, Thomale, Jürgen, Nist, Andrea, Wanzel, Michael, Stiewe, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838363/
https://www.ncbi.nlm.nih.gov/pubmed/26819410
http://dx.doi.org/10.1093/nar/gkw036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838363/
https://www.ncbi.nlm.nih.gov/pubmed/26819410
http://dx.doi.org/10.1093/nar/gkw036

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