RNA cleavage products generated by antisense oligonucleotides and siRNAs are processed by the RNA surveillance machinery

DNA-based antisense oligonucleotides (ASOs) elicit cleavage of the targeted RNA by the endoribonuclease RNase H1, whereas siRNAs mediate cleavage through the RNAi pathway. To determine the fates of the cleaved RNA in cells, we lowered the levels of the factors involved in RNA surveillance prior to t...

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Detalles Bibliográficos
Autores principales: Lima, Walt F., De Hoyos, Cheryl L., Liang, Xue-hai, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838368/
https://www.ncbi.nlm.nih.gov/pubmed/26843429
http://dx.doi.org/10.1093/nar/gkw065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838368/
https://www.ncbi.nlm.nih.gov/pubmed/26843429
http://dx.doi.org/10.1093/nar/gkw065

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