Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome

The antibiotic drug fusidic acid (FA) is commonly used in the clinic against gram-positive bacterial infections. FA targets ribosome-bound elongation factor G (EF-G), a translational GTPase that accelerates both messenger RNA (mRNA) translocation and ribosome recycling. How FA inhibits translocation...

Descripción completa

Detalles Bibliográficos
Autores principales: Borg, Anneli, Pavlov, Michael, Ehrenberg, Måns
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838388/
https://www.ncbi.nlm.nih.gov/pubmed/27001509
http://dx.doi.org/10.1093/nar/gkw178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838388/
https://www.ncbi.nlm.nih.gov/pubmed/27001509
http://dx.doi.org/10.1093/nar/gkw178

Ejemplares similares