Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. We built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic detail. Our results reveal that Pol II backtr...

Descripción completa

Detalles Bibliográficos
Autores principales: Da, Lin-Tai, Pardo-Avila, Fátima, Xu, Liang, Silva, Daniel-Adriano, Zhang, Lu, Gao, Xin, Wang, Dong, Huang, Xuhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838855/
https://www.ncbi.nlm.nih.gov/pubmed/27091704
http://dx.doi.org/10.1038/ncomms11244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838855/
https://www.ncbi.nlm.nih.gov/pubmed/27091704
http://dx.doi.org/10.1038/ncomms11244

Ejemplares similares