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Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. We built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic detail. Our results reveal that Pol II backtr...

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Detalles Bibliográficos
Autores principales:	Da, Lin-Tai, Pardo-Avila, Fátima, Xu, Liang, Silva, Daniel-Adriano, Zhang, Lu, Gao, Xin, Wang, Dong, Huang, Xuhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838855/ https://www.ncbi.nlm.nih.gov/pubmed/27091704 http://dx.doi.org/10.1038/ncomms11244

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