A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

BACKGROUND: Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis. Thus, the application of cathepsin S inhibitors may have clinical utility in the treatment of cancer. In this investigation, we appl...

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Detalles Bibliográficos
Autores principales: Wilkinson, Richard D. A., Young, Andrew, Burden, Roberta E., Williams, Rich, Scott, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839156/
https://www.ncbi.nlm.nih.gov/pubmed/27097645
http://dx.doi.org/10.1186/s12943-016-0513-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839156/
https://www.ncbi.nlm.nih.gov/pubmed/27097645
http://dx.doi.org/10.1186/s12943-016-0513-7

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