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A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

BACKGROUND: Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis. Thus, the application of cathepsin S inhibitors may have clinical utility in the treatment of cancer. In this investigation, we appl...

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Detalles Bibliográficos
Autores principales:	Wilkinson, Richard D. A., Young, Andrew, Burden, Roberta E., Williams, Rich, Scott, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839156/ https://www.ncbi.nlm.nih.gov/pubmed/27097645 http://dx.doi.org/10.1186/s12943-016-0513-7

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