Cargando…

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication

Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dhawan, Sangeeta, Dirice, Ercument, Kulkarni, Rohit N., Bhushan, Anil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839200/ https://www.ncbi.nlm.nih.gov/pubmed/26936960 http://dx.doi.org/10.2337/db15-1331

Ejemplares similares

Suppression of Latent Transforming Growth Factor (TGF)-β1 Restores Growth Inhibitory TGF-β Signaling through microRNAs
por: Dogar, Afzal M., et al.
Publicado: (2011)

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
por: Kolliopoulos, Constantinos, et al.
Publicado: (2019)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Cavβ3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner
por: Becker, Alexander, et al.
Publicado: (2021)

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells
por: Dominguez, Veronica, et al.
Publicado: (2011)

The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β
por: Craft, Clarissa S., et al.
Publicado: (2014)

Insulin Inhibits Cardiac Contractility by Inducing a G(i)-Biased β(2)-Adrenergic Signaling in Hearts
por: Fu, Qin, et al.
Publicado: (2014)

Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle
por: Bouzakri, Karim, et al.
Publicado: (2011)

HDLs Protect Pancreatic β-Cells Against ER Stress by Restoring Protein Folding and Trafficking
por: Pétremand, Jannick, et al.
Publicado: (2012)

Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells
por: James, Richard G., et al.
Publicado: (2013)

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2012)

Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak
por: Sun, Juan, et al.
Publicado: (2016)

The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca(2+) dynamics in adult mice
por: Mitchell, Ryan K., et al.
Publicado: (2017)

Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/β-Catenin Signaling Network
por: Lagathu, Claire, et al.
Publicado: (2009)

Amyloid-β Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway
por: Zhang, Yi, et al.
Publicado: (2012)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation
por: Nebel, Merle, et al.
Publicado: (2013)

Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E(2) Signaling and Enhances Diabetic β-Cell Function
por: Neuman, Joshua C., et al.
Publicado: (2017)

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin α(IIb)β(3) Activation and Granule Secretion in Platelets
por: Moore, Samantha F., et al.
Publicado: (2013)

Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in β Cells
por: Wuttke, Anne, et al.
Publicado: (2016)

Transforming Growth Factor β Promotes Complexes between Smad Proteins and the CCCTC-binding Factor on the H19 Imprinting Control Region Chromatin
por: Bergström, Rosita, et al.
Publicado: (2010)

Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation
por: Horbelt, Daniel, et al.
Publicado: (2015)

Activation of Intracellular Calcium by Multiple Wnt Ligands and Translocation of β-Catenin into the Nucleus: A CONVERGENT MODEL OF Wnt/Ca(2+) AND Wnt/β-CATENIN PATHWAYS
por: Thrasivoulou, Christopher, et al.
Publicado: (2013)

Disruption of Growth Factor Receptor–Binding Protein 10 in the Pancreas Enhances β-Cell Proliferation and Protects Mice From Streptozotocin-Induced β-Cell Apoptosis
por: Zhang, Jingjing, et al.
Publicado: (2012)

RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity
por: Koinuma, Daizo, et al.
Publicado: (2011)

Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc
por: Haller, Martina, et al.
Publicado: (2016)

Characterization of the β-d-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16
por: Sakurai, Takanobu, et al.
Publicado: (2010)

G Protein–Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta
por: Taguchi, Kumiko, et al.
Publicado: (2012)

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart
por: Capel, Rebecca A., et al.
Publicado: (2015)

Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production
por: Nistal-Villán, Estanislao, et al.
Publicado: (2010)

Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways
por: Coster, Adam D., et al.
Publicado: (2017)

Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin
por: Mishra, Jayshree, et al.
Publicado: (2017)

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ(1–40/42) and Phospho-Tau May Abet Alzheimer Development
por: Sajan, Mini, et al.
Publicado: (2016)

Zili Inhibits Transforming Growth Factor-β Signaling by Interacting with Smad4
por: Sun, Huaqin, et al.
Publicado: (2010)

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
por: Cunha, Daniel A., et al.
Publicado: (2012)

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin α(IIb)β(3) Outside-in Signaling
por: Battram, Anthony M., et al.
Publicado: (2017)

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4
por: Shukla, Arun K., et al.
Publicado: (2010)

Ca(2+)-mediated Mitochondrial Reactive Oxygen Species Metabolism Augments Wnt/β-Catenin Pathway Activation to Facilitate Cell Differentiation
por: Rharass, Tareck, et al.
Publicado: (2014)

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass
por: Blandino-Rosano, Manuel, et al.
Publicado: (2016)

Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
por: Soares, Marc A., et al.
Publicado: (2016)

β(2)-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function
por: Kim, Donghwa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_s29i7d5c3bsnv2j234k5rng8j8