Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6

The fetal tight junction molecule claudin 6 (CLDN6) is virtually absent from any normal tissue, whereas it is aberrantly and frequently expressed in various cancers of high medical need. We engineered 6PHU3, a T-cell-engaging bispecific single chain molecule (bi-(scFv)(2)) with anti-CD3/anti-CLDN6 s...

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Detalles Bibliográficos
Autores principales: Stadler, Christiane R., Bähr-Mahmud, Hayat, Plum, Laura M., Schmoldt, Kathrin, Kölsch, Anne C., Türeci, Özlem, Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839326/
https://www.ncbi.nlm.nih.gov/pubmed/27141353
http://dx.doi.org/10.1080/2162402X.2015.1091555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839326/
https://www.ncbi.nlm.nih.gov/pubmed/27141353
http://dx.doi.org/10.1080/2162402X.2015.1091555

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