Molecular Dynamics Simulations and Classical Multidimensional Scaling Unveil New Metastable States in the Conformational Landscape of CDK2

Protein kinases are key regulatory nodes in cellular networks and their function has been shown to be intimately coupled with their structural flexibility. However, understanding the key structural mechanisms of large conformational transitions remains a difficult task. CDK2 is a crucial regulator o...

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Detalles Bibliográficos
Autores principales: Pisani, Pasquale, Caporuscio, Fabiana, Carlino, Luca, Rastelli, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839568/
https://www.ncbi.nlm.nih.gov/pubmed/27100206
http://dx.doi.org/10.1371/journal.pone.0154066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839568/
https://www.ncbi.nlm.nih.gov/pubmed/27100206
http://dx.doi.org/10.1371/journal.pone.0154066

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