Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells

The CRISPR/Cas9 system has been applied in a large number of animal and plant species for genome editing. In chickens, CRISPR has been used to knockout genes in somatic tissues, but no CRISPR-mediated germline modification has yet been reported. Here we use CRISPR to target the chicken immunoglobuli...

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Detalles Bibliográficos
Autores principales: Dimitrov, Lazar, Pedersen, Darlene, Ching, Kathryn H., Yi, Henry, Collarini, Ellen J., Izquierdo, Shelley, van de Lavoir, Marie-Cecile, Leighton, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839619/
https://www.ncbi.nlm.nih.gov/pubmed/27099923
http://dx.doi.org/10.1371/journal.pone.0154303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839619/
https://www.ncbi.nlm.nih.gov/pubmed/27099923
http://dx.doi.org/10.1371/journal.pone.0154303

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