Cargando…

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

Dystrophin is expressed in differentiated myofibers where it is required for sarcolemmal integrity, and loss-of-function mutations in its gene result in Duchenne Muscular Dystrophy (DMD), a disease characterized by progressive and severe skeletal muscle degeneration. Here we found that dystrophin is...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumont, Nicolas A., Wang, Yu Xin, von Maltzahn, Julia, Pasut, Alessandra, Bentzinger, C. Florian, Brun, Caroline E., Rudnicki, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839960/
https://www.ncbi.nlm.nih.gov/pubmed/26569381
http://dx.doi.org/10.1038/nm.3990