The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell

AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also presen...

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Detalles Bibliográficos
Autores principales: Perrone, Rosalba, Butovskaya, Elena, Lago, Sara, Garzino-Demo, Alfredo, Pannecouque, Christophe, Palù, Giorgio, Richter, Sara N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840014/
https://www.ncbi.nlm.nih.gov/pubmed/27032748
http://dx.doi.org/10.1016/j.ijantimicag.2016.01.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840014/
https://www.ncbi.nlm.nih.gov/pubmed/27032748
http://dx.doi.org/10.1016/j.ijantimicag.2016.01.016

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