TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus

Linkage disequilibrium poses a major challenge to the functional characterization of specific disease-associated susceptibility variants. Precision genome editing technologies have provided new opportunities to address this challenge. As proof-of-concept, we employed TALEN-mediated genome editing to...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shaofeng, Wen, Feng, Tessneer, Kandice L., Gaffney, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840072/
https://www.ncbi.nlm.nih.gov/pubmed/26821284
http://dx.doi.org/10.1038/gene.2016.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840072/
https://www.ncbi.nlm.nih.gov/pubmed/26821284
http://dx.doi.org/10.1038/gene.2016.4

Ejemplares similares