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TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus

Linkage disequilibrium poses a major challenge to the functional characterization of specific disease-associated susceptibility variants. Precision genome editing technologies have provided new opportunities to address this challenge. As proof-of-concept, we employed TALEN-mediated genome editing to...

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Detalles Bibliográficos
Autores principales:	Wang, Shaofeng, Wen, Feng, Tessneer, Kandice L., Gaffney, Patrick M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840072/ https://www.ncbi.nlm.nih.gov/pubmed/26821284 http://dx.doi.org/10.1038/gene.2016.4

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