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Structure, toxicity and antibiotic activity of gramicidin S and derivatives

Development of new antibiotics is declining whereas antibiotic resistance is rising, heralding a post-antibiotic era. Antimicrobial peptides such as gramicidin S (GS), exclusively topically used due to its hemolytic side-effect, could still be interesting as therapeutic compounds. By modifying the a...

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Detalles Bibliográficos
Autores principales: Swierstra, J., Kapoerchan, V., Knijnenburg, A., van Belkum, A., Overhand, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840228/
https://www.ncbi.nlm.nih.gov/pubmed/26886453
http://dx.doi.org/10.1007/s10096-016-2595-y