MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner()()

PURPOSE: Increased murine double minute 2 (MDM2) expression, independent of p53 status, is associated with increased cancer-specific mortality for men with prostate cancer treated with radiotherapy. We assessed MI-219, a small molecule inhibitor of MDM2 with improved pharmacokinetics over nutlin-3,...

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Detalles Bibliográficos
Autores principales: Feng, Felix Y., Zhang, Yu, Kothari, Vishal, Evans, Joseph R., Jackson, William C., Chen, Wei, Johnson, Skyler B., Luczak, Connor, Wang, Shaomeng, Hamstra, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2016
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840291/
https://www.ncbi.nlm.nih.gov/pubmed/27108384
http://dx.doi.org/10.1016/j.neo.2016.01.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840291/
https://www.ncbi.nlm.nih.gov/pubmed/27108384
http://dx.doi.org/10.1016/j.neo.2016.01.006

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