Structure of FIV capsid C-terminal domain demonstrates lentiviral evasion of genetic fragility by coevolved substitutions

Viruses use a strategy of high mutational rates to adapt to environmental and therapeutic pressures, circumventing the deleterious effects of random single-point mutations by coevolved compensatory mutations, which restore protein fold, function or interactions damaged by initial ones. This mechanis...

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Detalles Bibliográficos
Autores principales: Khwaja, Aya, Galilee, Meytal, Marx, Ailie, Alian, Akram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840305/
https://www.ncbi.nlm.nih.gov/pubmed/27102180
http://dx.doi.org/10.1038/srep24957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840305/
https://www.ncbi.nlm.nih.gov/pubmed/27102180
http://dx.doi.org/10.1038/srep24957

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