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Dietary proanthocyanidins boost hepatic NAD(+) metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats

Proanthocyanidins (PACs) have been reported to modulate multiple targets by simultaneously controlling many pivotal metabolic pathways in the liver. However, the precise mechanism of PAC action on the regulation of the genes that control hepatic metabolism remains to be clarified. Accordingly, we us...

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Detalles Bibliográficos
Autores principales: Aragonès, Gerard, Suárez, Manuel, Ardid-Ruiz, Andrea, Vinaixa, Maria, Rodríguez, Miguel A., Correig, Xavier, Arola, Lluís, Bladé, Cinta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840337/
https://www.ncbi.nlm.nih.gov/pubmed/27102823
http://dx.doi.org/10.1038/srep24977