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Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody

Ectodomain shedding of glycoprotein (GP) Ibα is thought to mediate the clearance of activated, aged or damaged platelets. A monoclonal antibody, 5G6, has been developed recently to specifically bind to the GPIbα shedding cleavage site and to inhibit its shedding. However, the molecular mechanism und...

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Detalles Bibliográficos
Autores principales: Tao, Yue, Zhang, Xiaoqin, Liang, Xin, Zang, Jianye, Mo, Xi, Li, Renhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840364/
https://www.ncbi.nlm.nih.gov/pubmed/27102061
http://dx.doi.org/10.1038/srep24789