Lineage conversion induced by pluripotency factors involves transient passage through an iPS cell stage

Brief expression of pluripotency-associated factors such as Oct4, Klf4, Sox2 and c-Myc (OKSM), in combination with differentiation-inducing signals, was reported to trigger transdifferentiation of fibroblasts into other cell types. Here we show that OKSM expression in mouse fibroblasts gives rise to...

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Detalles Bibliográficos
Autores principales: Bar-Nur, Ori, Verheul, Cassandra, Sommer, Andreia Gianotti, Brumbaugh, Justin, Schwarz, Benjamin A., Lipchina, Inna, Huebner, Aaron J., Mostoslavsky, Gustavo, Hochedlinger, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840929/
https://www.ncbi.nlm.nih.gov/pubmed/26098450
http://dx.doi.org/10.1038/nbt.3247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840929/
https://www.ncbi.nlm.nih.gov/pubmed/26098450
http://dx.doi.org/10.1038/nbt.3247

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