Stochastic epigenetic outliers can define field defects in cancer

BACKGROUND: There is growing evidence that DNA methylation alterations may contribute to carcinogenesis. Recent data also suggest that DNA methylation field defects in normal pre-neoplastic tissue represent infrequent stochastic “outlier” events. This presents a statistical challenge for standard fe...

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Detalles Bibliográficos
Autores principales: Teschendorff, Andrew E., Jones, Allison, Widschwendter, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840974/
https://www.ncbi.nlm.nih.gov/pubmed/27103033
http://dx.doi.org/10.1186/s12859-016-1056-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840974/
https://www.ncbi.nlm.nih.gov/pubmed/27103033
http://dx.doi.org/10.1186/s12859-016-1056-z

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