Inhibition of Hb Binding to GP1bα Abrogates Hb-Mediated Thrombus Formation on Immobilized VWF and Collagen under Physiological Shear Stress

BACKGROUND: Reports including our own describe that intravascular hemolysis increases the risk of thrombosis in hemolytic disorders. Our recent study shows that plasma Hb concentrations correlate directly with platelet activation in patients with paroxysmal nocturnal hemoglobinuria (PNH). The bindin...

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Detalles Bibliográficos
Autores principales: Annarapu, Gowtham K., Singhal, Rashi, Peng, Yuandong, Guchhait, Prasenjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841505/
https://www.ncbi.nlm.nih.gov/pubmed/27105433
http://dx.doi.org/10.1371/journal.pone.0154276

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841505/
https://www.ncbi.nlm.nih.gov/pubmed/27105433
http://dx.doi.org/10.1371/journal.pone.0154276

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