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Bulk Genotyping of Biopsies Can Create Spurious Evidence for Hetereogeneity in Mutation Content
When multiple samples are taken from the neoplastic tissues of a single patient, it is natural to compare their mutation content. This is often done by bulk genotyping of whole biopsies, but the chance that a mutation will be detected in bulk genotyping depends on its local frequency in the sample....
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841575/ https://www.ncbi.nlm.nih.gov/pubmed/27105344 http://dx.doi.org/10.1371/journal.pcbi.1004413 |