Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration

BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of visual loss among the elderly. A key cell type involved in AMD, the retinal pigment epithelium, expresses a G protein–coupled receptor that, in response to its ligand, L-DOPA, up-regulates pigment epithelia–derived factor, whil...

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Detalles Bibliográficos
Autores principales: Brilliant, Murray H., Vaziri, Kamyar, Connor, Thomas B., Schwartz, Stephen G., Carroll, Joseph J., McCarty, Catherine A., Schrodi, Steven J., Hebbring, Scott J., Kishor, Krishna S., Flynn, Harry W., Moshfeghi, Andrew A., Moshfeghi, Darius M., Fini, M. Elizabeth, McKay, Brian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841631/
https://www.ncbi.nlm.nih.gov/pubmed/26524704
http://dx.doi.org/10.1016/j.amjmed.2015.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841631/
https://www.ncbi.nlm.nih.gov/pubmed/26524704
http://dx.doi.org/10.1016/j.amjmed.2015.10.015

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