Cargando…

Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration

BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of visual loss among the elderly. A key cell type involved in AMD, the retinal pigment epithelium, expresses a G protein–coupled receptor that, in response to its ligand, L-DOPA, up-regulates pigment epithelia–derived factor, whil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brilliant, Murray H., Vaziri, Kamyar, Connor, Thomas B., Schwartz, Stephen G., Carroll, Joseph J., McCarty, Catherine A., Schrodi, Steven J., Hebbring, Scott J., Kishor, Krishna S., Flynn, Harry W., Moshfeghi, Andrew A., Moshfeghi, Darius M., Fini, M. Elizabeth, McKay, Brian S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841631/ https://www.ncbi.nlm.nih.gov/pubmed/26524704 http://dx.doi.org/10.1016/j.amjmed.2015.10.015

Ejemplares similares

Incidence of bleb-associated endophthalmitis in the United States
por: Vaziri, Kamyar, et al.
Publicado: (2015)

Incidence of postoperative suprachoroidal hemorrhage after glaucoma filtration surgeries in the United States
por: Vaziri, Kamyar, et al.
Publicado: (2015)

Differences in anterior peripheral pathologic myopia and macular pathologic myopia by age and gender
por: Ludwig, Cassie A., et al.
Publicado: (2021)

Correction to: Differences in anterior peripheral pathologic myopia and macular pathologic myopia by age and gender
por: Ludwig, Cassie A., et al.
Publicado: (2023)

Pathology of Macular Foveoschisis Associated with Degenerative Myopia
por: Tang, Johnny, et al.
Publicado: (2010)

Telemedicine Applications in Pediatric Retinal Disease
por: Pathipati, Akhilesh S., et al.
Publicado: (2017)

Incontinentia pigmenti with secondary Raynaud's phenomenon: A case report and review of the literature
por: Greven, Margaret A., et al.
Publicado: (2016)

Retinal arterial tortuosity in Ehlers–Danlos syndromes
por: Ghoraba, Hashem H., et al.
Publicado: (2022)

Tamponade in the surgical management of retinal detachment
por: Vaziri, Kamyar, et al.
Publicado: (2016)

Endophthalmitis: state of the art
por: Vaziri, Kamyar, et al.
Publicado: (2015)

Retinal breaks due to intravitreal ocriplasmin
por: Silva, Ruwan A, et al.
Publicado: (2014)

Epidemiology of rhegmatogenous retinal detachment in commercially insured myopes in the United States
por: Ludwig, Cassie A., et al.
Publicado: (2023)

Methicillin-resistant Staphylococcus epidermidis isolation from the vitrectomy specimen four hours after initial treatment with vancomycin and ceftazidime
por: Javey, Golnaz, et al.
Publicado: (2010)

Biometric Variations in High Myopia Associated with Different Underlying Ocular and Genetic Conditions
por: Ghoraba, Hashem H., et al.
Publicado: (2022)

Statins and the progression of age-related macular degeneration in the United States
por: Ludwig, Cassie A., et al.
Publicado: (2021)

Screening and treatments using telemedicine in retinopathy of prematurity
por: Thanos, Aristomenis, et al.
Publicado: (2016)

Pilot Study of the Delivery of Microcollimated Pars Plana External Beam Radiation in Porcine Eyes: 270-Day Analysis
por: Singh, Rishi P., et al.
Publicado: (2012)

Multimodal Imaging of Posterior Dislocation of Crystalline Lens Nucleus following Vitrectomy
por: Karth, Peter A., et al.
Publicado: (2015)

How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration?
por: McCarty, Catherine A., et al.
Publicado: (2018)

Prevalence of Calcified Carotid Artery on Panoramic Radiographs in Postmenopausal Women
por: Taheri, Jamileh Beigom, et al.
Publicado: (2009)

Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia
por: Bartlett, Mitchell J., et al.
Publicado: (2020)

L-DOPA Is an Endogenous Ligand for OA1
por: Lopez, Vanessa M, et al.
Publicado: (2008)

Telemedicine Follow-Up for Intravitreal Bevacizumab Injection in the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) Cohort
por: Ji, Marco H, et al.
Publicado: (2020)

Traumatic chorioretinitis sclopetaria: Risk factors, management, and prognosis
por: Ludwig, Cassie A., et al.
Publicado: (2019)

Effective field of view of wide-field fundus photography in the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP)
por: Ji, Marco H., et al.
Publicado: (2022)

Cone Beam CT Analysis of Haller Cells: Prevalence and Relationship with Orbital Floor Dehiscence
por: Moshfeghi, Mahkameh, et al.
Publicado: (2023)

Morphological patterns of lip prints in an Iranian population
por: Moshfeghi, Mahkameh, et al.
Publicado: (2016)

Association of maternal and umbilical cord blood leptin concentrations and abnormal color Doppler indices of umbilical artery with fetal growth restriction
por: Zareaan, Elahe, et al.
Publicado: (2017)

Lingual Foramen of the Mandible on Cone-Beam Computed Tomography Scans: A Study of Anatomical Variations in an Iranian Population
por: Moshfeghi, Mahkameh, et al.
Publicado: (2021)

Relationship of Vitamin D Deficiency with Cervical Vertebral Maturation and Dental Age in Adolescents: A Cross-Sectional Study
por: Azarbakhsh, Golnoosh, et al.
Publicado: (2022)

Learning Red Hat Enterprise Linux and Fedora
por: McCarty, Bill, et al.
Publicado: (2004)

Conventional Versus Digital Radiography in Detecting Root Canal Type in Maxillary Premolars: An in Vitro Study
por: Moshfeghi, Mahkameh, et al.
Publicado: (2013)

Evaluation of the predictive value of fetal Doppler ultrasound for neonatal outcome from the 36(th) week of pregnancy
por: Eslamian, Zahra Laleh, et al.
Publicado: (2018)

Prevalence of Nasal Septum Deviation Using Cone-Beam Computed Tomography: A Cross-Sectional Study
por: Moshfeghi, Mahkameh, et al.
Publicado: (2020)

Does the size of an object containing dental implant affect the expression of artifacts in cone beam computed tomography imaging?
por: Moshfeghi, Mahkameh, et al.
Publicado: (2022)

Validation of PhenX measures in the personalized medicine research project for use in gene/environment studies
por: McCarty, Catherine A, et al.
Publicado: (2014)

L-DOPA
por: Hornykiewicz, Oleh
Publicado: (2017)

SeqHBase: a big data toolset for family based sequencing data analysis
por: He, Min, et al.
Publicado: (2015)

The comparison of clinical outcomes of endophthalmitis from fluoroquinolone-resistant and susceptible bacteria
por: Shirodkar, Anita R, et al.
Publicado: (2010)

The Effect of Aminopterin on the Autoxidation of Dopa
por: Lea, A. J.
Publicado: (1951)

Cannot write session to /tmp/vufind_sessions/sess_l11qqcdqebbbpc4ovonp2u7hb8