SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

The transcription factor SOX2 is central in establishing and maintaining pluripotency. The processes that modulate SOX2 activity to promote pluripotency are not well understood. Here, we show SOX2 is O-GlcNAc modified in its transactivation domain during reprogramming and in mouse embryonic stem cel...

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Detalles Bibliográficos
Autores principales: Myers, Samuel A, Peddada, Sailaja, Chatterjee, Nilanjana, Friedrich, Tara, Tomoda, Kiichrio, Krings, Gregor, Thomas, Sean, Maynard, Jason, Broeker, Michael, Thomson, Matthew, Pollard, Katherine, Yamanaka, Shinya, Burlingame, Alma L, Panning, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841768/
https://www.ncbi.nlm.nih.gov/pubmed/26949256
http://dx.doi.org/10.7554/eLife.10647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841768/
https://www.ncbi.nlm.nih.gov/pubmed/26949256
http://dx.doi.org/10.7554/eLife.10647

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