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RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress
The DNA replication machinery invariably encounters obstacles that slow replication fork progression, and threaten to prevent complete replication and faithful segregation of sister chromatids. The resulting replication stress activates ATR, the major kinase involved in resolving impaired DNA replic...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842010/ https://www.ncbi.nlm.nih.gov/pubmed/26549024 http://dx.doi.org/10.1038/onc.2015.427 |