Molecular Docking and In Silico ADMET Study Reveals Acylguanidine 7a as a Potential Inhibitor of β-Secretase

Amyloidogenic pathway in Alzheimer's disease (AD) involves breakdown of APP by β-secretase followed by γ-secretase and results in formation of amyloid beta plaque. β-secretase has been a promising target for developing novel anti-Alzheimer drugs. To test different molecules for this purpose, te...

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Detalles Bibliográficos
Autores principales: Nisha, Chaluveelaveedu Murleedharan, Kumar, Ashwini, Nair, Prateek, Gupta, Nityasha, Silakari, Chitrangda, Tripathi, Timir, Kumar, Awanish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842033/
https://www.ncbi.nlm.nih.gov/pubmed/27190510
http://dx.doi.org/10.1155/2016/9258578

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842033/
https://www.ncbi.nlm.nih.gov/pubmed/27190510
http://dx.doi.org/10.1155/2016/9258578

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