Unique role for ATG5 in PMN-mediated immunopathology during M. tuberculosis infection

Mycobacterium tuberculosis (Mtb), a major global health threat, replicates in macrophages (MΦ) in part by inhibiting phagosome-lysosome fusion, until IFN-γ activates the MΦ to traffic Mtb to the lysosome. How IFN-γ elicits this effect is unknown, but many studies suggest a role for macroautophagy (a...

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Detalles Bibliográficos
Autores principales: Kimmey, Jacqueline M., Huynh, Jeremy P., Weiss, Leslie A., Park, Sunmin, Kambal, Amal, Debnath, Jayanta, Virgin, Herbert W., Stallings, Christina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842313/
https://www.ncbi.nlm.nih.gov/pubmed/26649827
http://dx.doi.org/10.1038/nature16451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842313/
https://www.ncbi.nlm.nih.gov/pubmed/26649827
http://dx.doi.org/10.1038/nature16451

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