Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease

Endonuclease V (EndoV) is an enzyme with specificity for deaminated adenosine (inosine) in nucleic acids. EndoV from Escherichia coli (EcEndoV) acts both on inosines in DNA and RNA, whereas the human homolog cleaves only at inosines in RNA. Inosines in DNA are mutagenic and the role of EndoV in DNA...

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Detalles Bibliográficos
Autores principales: Nawaz, Meh Sameen, Vik, Erik Sebastian, Ronander, Mia Elise, Solvoll, Anne Marthe, Blicher, Pernille, Bjørås, Magnar, Alseth, Ingrun, Dalhus, Bjørn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842958/
https://www.ncbi.nlm.nih.gov/pubmed/27108838
http://dx.doi.org/10.1038/srep24979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842958/
https://www.ncbi.nlm.nih.gov/pubmed/27108838
http://dx.doi.org/10.1038/srep24979

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