1,25(OH)(2)D(3) dependent overt hyperactivity phenotype in klotho-hypomorphic mice

Klotho, a protein mainly expressed in kidney and cerebral choroid plexus, is a powerful regulator of 1,25(OH)(2)D(3) formation. Klotho-deficient mice (kl/kl) suffer from excessive plasma 1,25(OH)(2)D(3)-, Ca(2+)- and phosphate-concentrations, leading to severe soft tissue calcification and accelerat...

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Detalles Bibliográficos
Autores principales: Leibrock, Christina B., Voelkl, Jakob, Kuro-o, Makoto, Lang, Florian, Lang, Undine E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843009/
https://www.ncbi.nlm.nih.gov/pubmed/27109615
http://dx.doi.org/10.1038/srep24879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843009/
https://www.ncbi.nlm.nih.gov/pubmed/27109615
http://dx.doi.org/10.1038/srep24879

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