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Whi5 phosphorylation embedded in the G(1)/S network dynamically controls critical cell size and cell fate

In budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch—two central cell fate events—take place in the G(1) phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G(1)/S transition, whose major regulatory...

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Detalles Bibliográficos
Autores principales: Palumbo, Pasquale, Vanoni, Marco, Cusimano, Valerio, Busti, Stefano, Marano, Francesca, Manes, Costanzo, Alberghina, Lilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843020/
https://www.ncbi.nlm.nih.gov/pubmed/27094800
http://dx.doi.org/10.1038/ncomms11372