Efficient Synthesis of Nicotinamide-1-(15)N for Ultrafast NMR Hyperpolarization Using Parahydrogen

[Image: see text] Nicotinamide (a vitamin B(3) amide) is one of the key vitamins as well as a drug for treatment of M. tuberculosis, HIV, cancer, and other diseases. Here, an improved Zincke reaction methodology is presented allowing for straightforward and scalable synthesis of nicotinamide-1-(15)N...

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Detalles Bibliográficos
Autores principales: Shchepin, Roman V., Barskiy, Danila A., Mikhaylov, Dmitry M., Chekmenev, Eduard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843783/
https://www.ncbi.nlm.nih.gov/pubmed/26999571
http://dx.doi.org/10.1021/acs.bioconjchem.6b00148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843783/
https://www.ncbi.nlm.nih.gov/pubmed/26999571
http://dx.doi.org/10.1021/acs.bioconjchem.6b00148

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