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Efficient Synthesis of Nicotinamide-1-(15)N for Ultrafast NMR Hyperpolarization Using Parahydrogen
[Image: see text] Nicotinamide (a vitamin B(3) amide) is one of the key vitamins as well as a drug for treatment of M. tuberculosis, HIV, cancer, and other diseases. Here, an improved Zincke reaction methodology is presented allowing for straightforward and scalable synthesis of nicotinamide-1-(15)N...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843783/ https://www.ncbi.nlm.nih.gov/pubmed/26999571 http://dx.doi.org/10.1021/acs.bioconjchem.6b00148 |