Discovery of a regioselectivity switch in nitrating P450s guided by MD simulations and Markov models

The dynamic motions of protein structural elements, particularly flexible loops, are intimately linked with diverse aspects of enzyme catalysis. Engineering of these loop regions can alter protein stability, substrate binding, and even dramatically impact enzyme function. When these flexible regions...

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Detalles Bibliográficos
Autores principales: Dodani, Sheel C., Kiss, Gert, Cahn, Jackson K. B., Su, Ye, Pande, Vijay S., Arnold, Frances H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843824/
https://www.ncbi.nlm.nih.gov/pubmed/27102675
http://dx.doi.org/10.1038/nchem.2474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843824/
https://www.ncbi.nlm.nih.gov/pubmed/27102675
http://dx.doi.org/10.1038/nchem.2474

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