Selective inhibition of the kinase DYRK1A by targeting its folding process

Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has missed inhibitors that selectively interfere with the folding process. Here we report a cell-based assay that evaluates inhibition of a kinase a...

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Detalles Bibliográficos
Autores principales: Kii, Isao, Sumida, Yuto, Goto, Toshiyasu, Sonamoto, Rie, Okuno, Yukiko, Yoshida, Suguru, Kato-Sumida, Tomoe, Koike, Yuka, Abe, Minako, Nonaka, Yosuke, Ikura, Teikichi, Ito, Nobutoshi, Shibuya, Hiroshi, Hosoya, Takamitsu, Hagiwara, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844702/
https://www.ncbi.nlm.nih.gov/pubmed/27102360
http://dx.doi.org/10.1038/ncomms11391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844702/
https://www.ncbi.nlm.nih.gov/pubmed/27102360
http://dx.doi.org/10.1038/ncomms11391

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