USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites

USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes(1–9). Its effects on protein turnover are substrate specific, for unknown reasons. We report that USP14 shows a dramatic preference for ubiquitin-cyclin B conjugates that carry more than one...

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Detalles Bibliográficos
Autores principales: Lee, Byung-Hoon, Lu, Ying, Prado, Miguel A., Shi, Yuan, Tian, Geng, Sun, Shuangwu, Elsasser, Suzanne, Gygi, Steven P., King, Randall W., Finley, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844788/
https://www.ncbi.nlm.nih.gov/pubmed/27074503
http://dx.doi.org/10.1038/nature17433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844788/
https://www.ncbi.nlm.nih.gov/pubmed/27074503
http://dx.doi.org/10.1038/nature17433

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