Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines

High-content, image-based screens enable the identification of compounds that induce cellular responses similar to those of known drugs but through different chemical structures or targets. A central challenge in designing phenotypic screens is choosing suitable imaging biomarkers. Here we present a...

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Detalles Bibliográficos
Autores principales: Kang, Jungseog, Hsu, Chien-Hsiang, Wu, Qi, Liu, Shanshan, Coster, Adam D., Posner, Bruce A., Altschuler, Steven J., Wu, Lani F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844861/
https://www.ncbi.nlm.nih.gov/pubmed/26655497
http://dx.doi.org/10.1038/nbt.3419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844861/
https://www.ncbi.nlm.nih.gov/pubmed/26655497
http://dx.doi.org/10.1038/nbt.3419

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