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Improving drug discovery with high-content phenotypic screens by systematic selection of reporter cell lines
High-content, image-based screens enable the identification of compounds that induce cellular responses similar to those of known drugs but through different chemical structures or targets. A central challenge in designing phenotypic screens is choosing suitable imaging biomarkers. Here we present a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844861/ https://www.ncbi.nlm.nih.gov/pubmed/26655497 http://dx.doi.org/10.1038/nbt.3419 |