Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

The neuronal accumulation of phosphorylated tau plays a critical role in the pathogenesis of Alzheimer’s disease (AD). Here, we examined the effect of fisetin, a flavonol, on tau levels. Treatment of cortical cells or primary neurons with fisetin resulted in significant decreases in the levels of ph...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Sunhyo, Choi, Ki Ju, Cho, Sun-Jung, Yun, Sang-Moon, Jeon, Jae-Pil, Koh, Young Ho, Song, Jihyun, Johnson, Gail V. W., Jo, Chulman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844953/
https://www.ncbi.nlm.nih.gov/pubmed/27112200
http://dx.doi.org/10.1038/srep24933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844953/
https://www.ncbi.nlm.nih.gov/pubmed/27112200
http://dx.doi.org/10.1038/srep24933

Ejemplares similares